Students

Andrea Goya Grocin

Andrea Goya Grocin

3rd year PhD

Project: Understanding dysregulation of protein lipidation in cancer

Biography:

Project: Understanding dysregulation of protein lipidation in cancer

Supervisor: Prof Ed Tate

CRUK PhD Studentship
About Me
After graduating on a Bachelor’s degree in Biochemistry and Molecular Biology from the University of the Basque Country (Spain), I moved to London to advance in my research career. I undertook the MRes in Biomedical Research at Imperial College London, which gave me the opportunity to complete two six- month-projects in two cutting edge laboratories in the heart of London. This offered me priceless research training and motivated me to continue my research path one step further into my PhD. During my master’s degree I was awarded a Cancer Research UK PhD studentship to join Prof Ed Tate’s group at Imperial College London.
Research Interests
My current research in Prof Ed Tate’s group at the Institute of Chemical Biology focuses on protein lipidation and how this essential process may be dysregulated in cancer. Protein lipidation is a common type of post-translational modification (PTM) in which a fatty acid is covalently attached to a protein, regulating its activity, function and cellular localisation. This process is now well established to play a crucial role in cancer development and progression, with various lipidation events having shown to be essential for normal function of well-known oncoproteins. My research consists of understanding how this type of protein regulation is changed in different cancer models using a quantitative novel approach for studying lipidation across the proteome. This will enable us to generate and test new hypothesis on how cancer cells may be vulnerable to inhibitors of protein lipidation pathways, generating new targets for potential anti-cancer therapies.
Teaching
I am currently helping at ‘lab pods’ as a Graduate Teaching Assistant for first-year undergraduate students in the Bachelor’s in Medical Biosciences, here at Imperial.
In this ‘new generation’ of lab practical sessions the students are given the freedom to propose their own aims and hypothesis as well as to plan their own experiments. We are there to help them shape those goals, aid in the design of their experiments and, of course, solve all their queries!
Outreach
Thanks to the various outreach opportunities the CRUK offers, I recently discovered how much I enjoy talking about my research and what cancer research means to the public!
In the past year I’ve taken part in the Imperial Festival, giving lab tours of our own lab to people from all ages and in the Imperial Fringe at White City to promote the opening of the new campus within the local community.
Conferences & Courses
• 10th MaxQuant Summer School on Computational Mass Spectrometry-Based Proteomics (Planned, July 2018)
• 11th Annual ABPP Meeting: Target Discovery Using Chemical Probes, Oxford (March 2018)

• Proteomics in Cell Biology and Disease Mechanisms, Wellcome Genome Campus, Hinxton (Feb 2018)

• 1st Crick Cancer Conference (Oct 2017)

Contact Details
a.goya-grocin15@imperial.ac.uk