Chris Douse

Chris Douse


Project: Dynamics of the Plasmodium Invasion Motor Complex: A Novel Target for Anti-Malarial Therapy


I began my undergraduate degree in Chemistry at the University of Oxford in 2005. My final year project in the lab of Dr Luet Wong, engineering non-natural substrate oxidation by cytochrome P450 enzymes, sparked an interest in protein science and I joined the ICB for a 1+3 year MRes/PhD in Chemical Biology in October 2009.

I now work under the supervision of Dr Ed Tate (Chemistry) and Dr Ernesto Cota (Molecular Biosciences) at Imperial, in a collaborative project with Prof Tony Holder at the MRC National Institute of Medical Research. I have been using a variety of biophysical methods including high field NMR spectroscopy to explore at atomic resolution the structural and dynamic features of a protein-protein interaction involved in the motility of Plasmodium falciparum parasites, the pathogens responsible for human malaria. I am particularly interested in using the detailed information obtained by such experiments to design molecules that might be able to reliably perturb such a complex biological system. In this way we hope to address fundamental biological questions as well as give insights into drug development.