Research

Emma Couves

Novel adjuvants for antibody-based cancer therapeutics: design, biological characterization and influence on membrane-protein structure.

Emma Couves - 1st year PhD

Abstract

The membrane attack complex (MAC) is a lytic immune pore that acts in part during cancer immunotherapy treatments. CD59 is the only membrane-bound regulator of the MAC, and is over-expressed on cancer cells.
This proposal takes an interdisciplinary approach, integrating structural biology alongside physical and synthetic chemistry, to define the molecular mechanism of action of CD59, and to enable design and iterative improvement of novel biomimetic CD59 inhibitors that could have potential therapeutic applications in cancer immunotherapy.