Richard Thistlethwaite

Chemical probes to enable next-generation fungicides – preparing for the impact of climate change

Richard Thistlethwaite - 3rd year PhD


Many pathogenic fungi which cause crop diseases are notorious for their ability to evolve rapidly. They can adapt to environmental changes and swiftly develop resistance to the fungicides farmers use to control them. Climate change and global warming in particular therefore poses a serious risk to food security due to potential increases in fungal infections to crops and rapid obsolescence of current fungicides used to control them. In this project we will use a chemical proteomics approach to map the metabolic interactome of certain fungicides (e.g. strobilurins) so as to increase our understanding of resistance mechanisms and inform the future development of next-generation fungicides with reduced susceptibility to the metabolizing enzymes that lead to resistance and consequent ineffectiveness.