Research

CDT Student Presentations & Publications

National and international presentations

Our CDT student cohort gives around 70 presentations per year at internal events, such as the Postgraduate Symposium, Imperial College London (ca. 20 posters and 15 talks by our CDT students p.a.) and the Joint CDT Conference (ca. 20 posters and 15 talks by our CDT students p.a.).

They have given 170 additional national and international presentations since 2008 of which 67% are posters and 33% are oral presentations.

Publications and Citations

* correct on 25th April 2014

 

List of Publications

2014

2. E. W. Tate, A. S. Bell, M. D. Rackham and M. H. Wright, "N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis", Parasitology, 2013, DOI: 10.1017/S0031182013000450
3. N. R. Roque Rosell et al.,” Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease”, Bioorganic & medicinal chemistry letters, 2014, 24, 490-494.
4. C. J. Dickson et al.,”Lipid14: The Amber Lipid Force Field”, Journal of Chemical Theory and Computation, 2014, 10, 865-879.
5. D. Casey et al. “Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature”, Journal of the Royal Society Interface, 2014, 11.
 

2013

3.V. A. Turek et al., “Self-Assembly and Applications of Ultraconcentrated Nanoparticle Solutions”,Acs Nano, 2013, 7, 8753-8759.
4.L. D. Smith et al.,”Development of small molecules to target the IgE:Fc epsilon RI protein-protein interaction in allergies”, Future Medicinal Chemistry, 2013, 5, 1423-1435.
5.J. J. P. Sejberg et al., “Enantioselective synthesis of (+)-aspercyclide A“,  Tetrahedron Letters, 2013, 54, 4970-4972.
6.A. Salehi-Reyhani et al., "Scaling Advantages and Constraints in Miniaturized Capture Assays for Single Cell Protein Analysis", Lab on a Chip, 2013, DOI: 10.1039/C1033LC41388H.
8.H. B. Manning et al., "Detection of cartilage matrix degradation by autofluorescence lifetime", Matrix biology : Journal of the International Society for Matrix Biology, 2013, 32, 32-38.
9.C. V. Kulkarniet al., "Pressure effects on a protein-lipid model membrane", Soft Matter, 2013, 9, 6525-6531.
10.M. L. Kirsten et al., "Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy", Molecular Membrane Biology, 2013, 30, 303-314.
11.Y. Elani et al., "Engineering multi-compartment vesicle networks",Chemical Science, 2013, 4, 3332-3338.
12.F. L. Cherblanc et al., "Perspectives on natural product epigenetic modulators in chemical biology and medicine", Natural Product Reports, 2013, DOI: 10.1039/C1033NP20097C.
13.A. Haslop, A. Gee, C. Plisson and N. Long, "Fully automated radiosynthesis of [1-(2-[18F]fluoroethyl),1H[1,2,3]triazole 4-ethylene] triphenylphosphonium bromide as a potential positron emission tomography tracer for imaging apoptosis", Journal of Labelled Compounds and Radiopharmaceuticals, 2013, DOI: 10.1002/jlcr.3024.
15.B. Carroll et al., "The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy", Developmental Cell, 2013, 25, 15-28

2012

1. A. Wormit et al., "Osmosensitive Changes of Carbohydrate Metabolism in Response to Cellulose Biosynthesis Inhibition", Plant Physiology, 2012, 159, 105-117.
2. S. A. J. Rosen, P. R. J. Gaffney, B. Spiess and I. R. Gould, "Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates", Phys. Chem. Chem. Phys., 2012, 14, 929-936.
3. H. P. Price et al., "A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei", BBA - Molecular Cell Res., 2012, 1823, 1178-1191.
4. R. Patalay et al., "Multiphoton Multispectral Fluorescence Lifetime Tomography for the Evaluation of Basal Cell Carcinomas", PLoS One, 2012, 7.
5. R. H. Nonoo, A. Armstrong and D. J. Mann, "Kinetic Template-Guided Tethering of Fragments", ChemMedChem, 2012, 7, 2082-2086.
6. L. H. Mak et al., "Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases", Bioorg. Med. Chem., 2012, 20, 4371-4376.
7. R. Laine et al., "Fluorescence Lifetime Readouts of Troponin-C-Based Calcium FRET Sensors: A Quantitative Comparison of CFP and mTFP1 as Donor Fluorophores", PLoS One, 2012, 7.
8. K.-K. Ho et al., "Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin", J. Biol. Chem., 2012, 287, 1545-1555.
9. W. P. Heal, M. H. Wright, E. Thinon and E. W. Tate, "Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry", Nature Protocols, 2012, 7, 105-117.
10. S.-u. Hassan, F. Gielen, X. Niu and J. B. Edel, "Controlled one dimensional oscillation of the Belousov-Zhabotinsky reaction confined within microchannels", RSC Advances, 2012, 2, 6408-6410.
11. M. S. Goyder et al., "Affinity chromatography and capillary electrophoresis for analysis of the yeast ribosomal proteins", BMB Reports, 2012, 45, 233-238.
12. F. Gielen, A. J. deMello and J. B. Edel, "Dielectric Cell Response in Highly Conductive Buffers", Anal. Chem., 2012, 84, 1849-1853.
13. S. Furse et al., "Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate", Soft Matter, 2012, 8, 3090-3093.
14. Y. Elani, A. J. deMello, X. Niu and O. Ces, "Novel technologies for the formation of 2-D and 3-D droplet interface bilayer networks", Lab on a Chip, 2012, 12, 3514-3520.
15. C. H. Douse et al., "Regulation of the Plasmodium Motor Complex: Phosphorylation of Myosin A Tail-Interacting Protein (MTIP) loosens its grip on MyoA", J. Biol. Chem., 2012, 287, 36968-36977.
16. C. J. Dickson et al., "GAFFlipid: a General Amber Force Field for the accurate molecular dynamics simulation of phospholipid", Soft Matter, 2012, 8, 9617-9627.
17. R. Crawford, D. J. Kelly and A. N. Kapanidis, "A Protein Biosensor That Relies on Bending of Single DNA Molecules", ChemPhysChem, 2012, 13, 918-922.
18. R. T. Bradshaw et al., "Mutational Locally Enhanced Sampling (MULES) for quantitative prediction of the effects of mutations at protein-protein interfaces", Chem. Sci., 2012, 3, 1503-1511.
19. A. S. Bell et al., "Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs", PLoS Neglected Tropical Diseases, 2012, 6.
20. D. Alibhai et al., "Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation", Journal of Biophotonics, 2012, DOI: 10.1002/jbio.201200185

2011

1. D. S. Ushakov et al., "Response of Rigor Cross-bridges to Stretch Detected by Fluorescence Lifetime Imaging Microscopy of Myosin Essential Light Chain in Skeletal Muscle Fibers", J. Biol. Chem., 2011, 286, 842-850.
2. C. B. Talbot et al., "Application of ultrafast gold luminescence to measuring the instrument response function for multispectral multiphoton fluorescence lifetime imaging", Optics Express, 2011, 19, 13848-13861.
3. A. J. Surman et al., "Targeting of anionic membrane species by lanthanide(III) complexes: towards improved MRI contrast agents for apoptosis", Chem. Comm., 2011, 47, 10245-10247.
4. S. F. Stuart, R. J. Leatherbarrow and K. R. Willison, "A Two-step Mechanism for the Folding of Actin by the Yeast Cytosolic Chaperonin", J. Biol. Chem., 2011, 286, 178-184.
5. V. Y. Soloviev et al., "Forster resonance energy transfer imaging in vivo with approximated radiative transfer equation", Applied Optics, 2011, 50, 6583-6590.
6. A. Salehi-Reyhani et al., "A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection", Lab on a Chip, 2011, 11, 1256-1261.
7. S. A. J. Rosen, P. R. J. Gaffney and I. R. Gould, "A theoretical investigation of inositol 1,3,4,5-tetrakisphosphate", Phys. Chem. Chem. Phys., 2011, 13, 1070-1081.
8. X. Niu, F. Gielen, J. B. Edel and A. J. deMello, "A microdroplet dilutor for high-throughput screening", Nature Chemistry, 2011, 3, 437-442.
9. J. McGinty et al., "In vivo fluorescence lifetime tomography of a FRET probe expressed in mouse", Biomedical Optics Express, 2011, 2, 1907-1917.
10. L. H. Mak et al., "A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain", ACS Chem. Biol., 2011, 6, 1382-1390.
11. R. Macey, O. Ces, A. Gee and N. Long, "Predicting and measuring the in vitro non-specific binding of a series of drug analogues", Journal of Labelled Compounds & Radiopharmaceuticals, 2011, 54, S126-S126.
12. S. Kumar et al., "High-speed 2D and 3D fluorescence microscopy of cardiac myocytes", Optics Express, 2011, 19, 13839-13847.
13. S. Kumar et al., "FLIM FRET Technology for Drug Discovery: Automated Multiwell-Plate High-Content Analysis, Multiplexed Readouts and Application in Situ", ChemPhysChem, 2011, 12, 609-626.
14. W. P. Heal et al., "Bioorthogonal chemical tagging of protein cholesterylation in living cells", Chem. Comm., 2011, 47, 4081-4083.
15. R. Guo et al., "Potential for the detection of molecular complexes and determination of interaction geometry by 2DIR: Application to protein sciences", Faraday Discussions, 2011, 150, 161-174.
16. S. Grippon et al., "Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway", Nucleic Acids Research, 2011, 39, 2593-2603.
17. C. J. Dickson et al., "Further evaluation of quantum chemical methods for the prediction of non-specific binding of positron emission tomography tracers", Phys. Chem. Chem. Phys., 2011, 13, 21552-21557.
18. A. C. N. Brown et al., "Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy", PLoS biology, 2011, 9, e1001152-e1001152.
19. R. T. Bradshaw et al., "Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction", Prot. Eng. Des. Sel., 2011, 24, 197-207.

2010

1. P. A. Zunszain et al., "Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate", J. Mol. Biol., 2010, 395, 375-389.
2. M. E. B. Smith et al., "Development of chemical probes: Toward the mode of action of a methylene-linked di(aryl acetate) E1", Bioorg. Med. Chem., 2010, 18, 4917-4927.
3. M. A. Purbhoo et al., "Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse", Science Signaling, 2010, 3.
4. D. M. Owen et al., "High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells", Molecular Membrane Biology, 2010, 27, 178-189.
5. D. M. Owen, K. Gaus, A. I. Magee and M. Cebecauer, "Dynamic organization of lymphocyte plasma membrane: lessons from advanced imaging methods", Immunology, 2010, 131, 1-8.
6. C. E. McKenna et al., "Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo 1,2-a pyridin-3-yl-2-phosphonopropionic Acid", J. Med. Chem., 2010, 53, 3454-3464.
7. J. Martinelli et al., "Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies", Dalton Transactions, 2010, 39, 10056-10067.
8. C. V. Kulkarni et al., "Engineering bicontinuous cubic structures at the nanoscale-the role of chain splay", Soft Matter, 2010, 6, 3191-3194.
9. K. Koehler et al., "Matched Sizes of Activating and Inhibitory Receptor/Ligand Pairs Are Required for Optimal Signal Integration by Human Natural Killer Cells", PLoS One, 2010, 5.
10. G. T. Kennedy et al., "A fluorescence lifetime imaging scanning confocal endomicroscope", Journal of Biophotonics, 2010, 3, 103-107.
11. F. Gielen, F. Pereira, A. J. deMello and J. B. Edel, "High-Resolution Local Imaging of Temperature in Dielectrophoretic Platforms", Anal. Chem., 2010, 82, 7509-7514.
12. C. R. Drake et al., "Bioresponsive Small Molecule Polyamines as Noncytotoxic Alternative to Polyethylenimine", Molecular Pharmaceutics, 2010, 7, 2040-2055.
13. P. M. Donaldson, K. R. Willison and D. R. Klug, "Generation of Simplified Protein Raman Spectra Using Three-Color Picosecond Coherent Anti-Stokes Raman Spectroscopy", J. Phys. Chem. B, 2010, 114, 12175-12181.
14. E. S. Child et al., "A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding", BBA - Molecular Cell Res., 2010, 1803, 858-864.
15. A. F. H. Berry et al., "Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry", ChemBioChem, 2010, 11, 771-773.
16. M. H.Wright, W. P. Heal, D. J. Mann and E. W. Tate, "Protein myristoylation in health and disease", J. Chem. Biol., 2010, 3, 19-35

2009

1. G. C. Shearman et al., "A 3-D Hexagonal Inverse Micellar Lyotropic Phase", J. Am. Chem. Soc., 2009, 131, 1678-+.
2. A. M. Seddon et al., "Drug interactions with lipid membranes", Chem. Soc. Rev., 2009, 38, 2509-2519.
3. Y. Schaerli et al., "Continuous-Flow Polymerase Chain Reaction of Single-Copy DNA in Microfluidic Microdroplets", Anal. Chem., 2009, 81, 302-306.
4. T. Robinson et al., "Removal of background signals from fluorescence thermometry measurements in PDMS microchannels using fluorescence lifetime imaging", Lab on a Chip, 2009, 9, 3437-3441.
5. X. Niu, F. Gielen, A. J. deMello and J. B. Edel, "Electro-Coalescence of Digitally Controlled Droplets", Anal. Chem., 2009, 81, 7321-7325.
6. X. Mulet et al., "Spatial localization of PtdInsP2 in phase-separated giant unilamellar vesicles with a fluorescent PLC-delta 1 PH domain", Methods in Molecular Biology, 2009, 462, 135-144.
7. M.-C. Miller et al., "Membrane Type 1 Matrix Metalloproteinase Is a Crucial Promoter of Synovial Invasion in Human Rheumatoid Arthritis", Arthritis and Rheumatism, 2009, 60, 686-697.
8. J. McGinty et al., "Three-dimensional imaging of Forster resonance energy transfer in heterogeneous turbid media by tomographic fluorescent lifetime imaging", Optics Letters, 2009, 34, 2772-2774.
9. K.-K. Ho et al., "The novel molecule 2- 5-(2-chloroethyl)-2-acetoxy-benzyl -4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells", FEBS Journal, 2009, 276, 4037-4050.
10. R. Guo et al., "Detection of complex formation and determination of intermolecular geometry through electrical anharmonic coupling of molecular vibrations using electron-vibration-vibration two-dimensional infrared spectroscopy", Phys. Chem. Chem. Phys., 2009, 11, 8417-8421.
11. F. Gielen, A. J. deMello, T. Cass and J. B. Edel, "Increasing the Trapping Efficiency of Particles in Microfluidic Planar Platforms by Means of Negative Dielectrophoresis", J. Phys. Chem. B, 2009, 113, 1493-1500.
12. F. Fournier et al., "Biological and Biomedical Applications of Two-Dimensional Vibrational Spectroscopy: Proteomics, Imaging, and Structural Analysis", Acc. Chem. Res., 2009, 42, 1322-1331.
13. F. J. Culley et al., "Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration", PLoS Biology, 2009, 7.
14. M. Cebecauer, D. M. Owen, A. Markiewicz and A. I. Magee, "Lipid order and molecular assemblies in the plasma membrane of eukaryotic cells", Biochem. Soc. Trans., 2009, 37, 1056-1060.

2008

1. P. Thongyoo, N. Roque-Rosell, R. J. Leatherbarrow and E. W. Tate, "Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides", Org. Biomol. Chem., 2008, 6, 1462-1470.
2. C. B. Talbot et al., "High speed unsupervised fluorescence lifetime imaging confocal multiwell plate reader for high content analysis", Journal of Biophotonics, 2008, 1, 514-521.
3. S. Sowinski et al., "Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission", Nature Cell Biology, 2008, 10, 211-219.
4. T. Robinson et al., "Three-dimensional molecular mapping in a microfluidic mixing device using fluorescence lifetime imaging", Optics Letters, 2008, 33, 1887-1889.
5. V. Poher et al., "Improved sectioning in a slit scanning confocal microscope", Optics Letters, 2008, 33, 1813-1815.
6. S. Oddos et al., "High-Speed High-Resolution Imaging of Intercellular Immune Synapses Using Optical Tweezers", Biophys. J., 2008, 95, L66-L68.
7. D. Nicolau, P. Driscoll, P. Gaffney and A. Tabor, "Solid-phase synthesis of lantibiotics: Synthesis and structure of an analogue of the C-terminus of Nisin", J. Pept. Sci., 2008, 14, 12-12.
8. X. Mulet, R. H. Templer, R. Woscholski and O. Ces, "Evidence that phosphatidylinositol promotes curved membrane interfaces", Langmuir, 2008, 24, 8443-8447.
9. J. McGinty et al., "Fluorescence lifetime optical projection tomography", Journal of Biophotonics, 2008, 1, 390-394.
10. H. B. Manning et al., "A compact, multidimensional spectrofluorometer exploiting supercontinuum generation", Journal of Biophotonics, 2008, 1, 494-505.
11. R. M. Gunn and H. C. Hailes, "Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules", J. Chem. Biol., 2008, 1, 49-62.
12. D. M. Grant et al., "Multiplexed FRET to Image Multiple Signaling Events in Live Cells", Biophys. J., 2008, 95, L69-L71.
13. D. L. Gater, J. M. Seddon and R. V. Law, "Formation of the liquid-ordered phase in fully hydrated mixtures of cholesterol and lysopalmitoylphosphatidylcholine", Soft Matter, 2008, 4, 263-267.
14. F. Fournier et al., "Protein identification and quantification by two-dimensional infrared spectroscopy: Implications for an all-optical proteomic platform", Proc. Nat. Acad. Sci., 2008, 105, 15352-15357.
15. F. Fournier et al., "Optical fingerprinting of peptides using two-dimensional infrared spectroscopy: Proof of principle", Anal. Biochem., 2008, 374, 358-365.
16. R. Felstead, S. E. Gibson, A. Rooney and E. S. Y. Tse, "A Stereocontrolled Approach to Ethers with Two alpha Stereocentres", Eur. J. Org. Chem., 2008, 4963-4971.
17. C. E. Conn et al., "A pressure-jump time-resolved x-ray diffraction study of cubic-cubic transition kinetics in monoolein", Langmuir, 2008, 24, 2331-2340.
18. D. R. Casey et al., "Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs", Industrial & Engineering Chemistry Research, 2008, 47, 650-655.
19. G. K. Busch et al., "Specific N-terminal protein labelling: use of FMDV 3C(pro) protease and native chemical ligation", Chem. Comm., 2008, 3369-3371.
20. S. H. Alley, O. Ces, R. H. Templer and M. Barahona, "Biophysical regulation of lipid biosynthesis in the plasma membrane", Biophys. J., 2008, 94, 2938-2954.
21. S. H. Alley, O. Ces, M. Barahona and R. H. Templer, "X-ray diffraction measurement of the monolayer spontaneous curvature of dioleoylphosphatidylglycerol", Chemistry and Physics of Lipids, 2008, 154, 64-67.

2007

1. T. R. Sweeney et al., "Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis", Journal of Virology, 2007, 81, 115-124.
2. D. M. Owen, M. A. A. Neil, P. M. W. French and A. I. Magee, "Optical techniques for imaging membrane lipid microdomains in living cells", Seminars in Cell & Developmental Biology, 2007, 18, 591-598.
3. D. M. Owen et al., "Excitation-resolved hyperspectral fluorescence lifetime imaging using a UV-extended supercontinuum source", Optics Letters, 2007, 32, 3408-3410.
4. V. S. Lopes et al., "The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium", Traffic, 2007, 8, 486-499.
5. A. M. Jaulent et al., "A continuous assay for foot-and-mouth disease virus 3C protease activity", Anal. Biochem., 2007, 368, 130-137.
6. P. M. Donaldson et al., "Direct identification and decongestion of Fermi resonances by control of pulse time ordering in two-dimensional IR spectroscopy", J. Chem. Phys., 2007, 127, 114513-114513.
7. S. Curry, N. Roque-Rosell, P. A. Zunszain and R. J. Leatherbarrow, "Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target", International Journal of Biochemistry & Cell Biology, 2007, 39, 1-6.

2006

1. B. Treanor et al., "Microclusters of inhibitory killer immunoglobulin like receptor signaling at natural killer cell immunological synapses", J. Cell Biol., 2006, 174, 153-161.
2. H. S. Rzepa, A. Wheat and M. J. Williamson, "ChemSem: An extensible and scalable RSS-based seminar alerting system for scientific collaboration", J. Chem. Inf. Model., 2006, 46, 985-990.
3. E. Rosivatz et al., "A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)", ACS Chem. Biol., 2006, 1, 780-790.
4. D. M. Owen et al., "Fluorescence lifetime imaging provides enhanced contrast when imaging the phase-sensitive dye di-4-ANEPPDHQ in model membranes and live cells", Biophys. J., 2006, 90, L80-L82.
5. C. E. Conn et al., "Dynamics of structural transformations between lamellar and inverse bicontinuous cubic lyotropic phases", Physical Review Letters, 2006, 96.

2005

1. E. H. Clay and I. R. Gould, "A combined QM and MM investigation into guanine quadruplexes", J. Mol. Graph. Model., 2005, 24, 138-146.